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Synthesis of a tritiated guanosine analog as a substrate for purine nucleoside phosphorylase. Phosphorolytic cleavage of the N-glycosylic bond of 1-beta-D-arabinofuranosylcytosine (ara-C), an active form of cytosine arabinoside (cytarabine), leads to formation of the purine nucleoside triphosphate, 1-beta-D-arabinofuranosylcytosine triphosphate (ara-CTP), and 1-beta-D-arabinofuranosylcytosine diphosphate (ara-CDP). This reaction was investigated in regard to the synthesis of the labelled ara-C analog, N-tritiated ara-C. This compound is considered a potential substrate for purine nucleoside phosphorylase (PNP), a potential target for new cytotoxic drugs, but is so far not available. Synthetic procedures for this compound are described in the present article.Q: How to use async await in nodejs with internal asynchronous loops? Let's say I have a function where I use fs.readdir which reads a directory and returns a list of its contents. // MyFunction const fs = require('fs') const contents = fs.readdir(__dirname) for(const contents of contents){ // do stuff } As readdir is asynchronous and can't be used synchronously, and we can't use await inside the internal loop, what's the right way to go about this? Should I just use a promise and then use.then() on the results to get the promises back? A: You are looking for Promises. They are easy to work with, no need to use any internal asynchronous loops (callback hell). Example: fs.readdir(__dirname) .then((files) => { files.forEach(file => { // do stuff }); }); Read about promises in the docs Q: Extracting values from list of dictionaries I am trying to extract the values from
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